During experiments on the axons of the Woods Hole squid (loligo pealei), we tested our cockroach leg stimulus protocol on the squid's chromatophores.

 

 The results were both interesting and beautiful. The video is a view through an 8x microscope zoomed in on the dorsal side of the caudal fin of the squid. We used a suction electrode to stimulate the fin nerve. Chromatophores are pigmeted cells that come in 3 colors: Brown, Red, and Yellow. Each chromatophore is lined with up to 16 muscles that contract to reveal their color.

Paloma T. Gonzalez-Bellido of Roger Hanlon's Lab in the Marine Resource Center of the Marine Biological Labs helped us with the preparation. You can read their latest paper at:http://rspb.royalsocietypublishing.org/content/early/2012/08/13/rspb.2012.1374

STAR WARS DETOURS™ Trailer

The nine people believed injured by stray police gunfire outside the Empire State Building were not the first to learn how dangerous a crowded street can be in a gunfight.

 Civilians occasionally find themselves in harm's way when officers use deadly force, though usually only a handful of times annually. When that happens, a rigid process of investigation is set in motion — and the police department can reasonably expect a lawsuit. The latest episode came when police say a man disgruntled over losing his job a year ago shot a former colleague to death and pointed his weapon at two police officers in the shadow of a major tourist attraction. He apparently wasn't able to fire before police killed him, one firing off seven rounds and the other nine. Bystanders suffered graze wounds, and some were struck by concrete gouged from buildings by the bullets, authorities said. At least one person said he was actually hit by a bullet. Robert Asika, a 23-year-old tour guide who was hit in the right arm, said he was "100 percent positive" he was shot by a police officer. A witness told police that laid-off clothing designer Jeffrey Johnson fired at officers, but ballistics evidence so far contradicts that, authorities said.

Tracking a Rare Tattoo-Related Infection

A Trail of Ink: Tracking a Rare Tattoo-Related Infection

An uncommon skin infection led to a doctor's investigation into tainted tattoo ink. (Monroe County Health Department)

The reddish-purple rash, seemingly woven into the tattoo on a 20-year-old New Yorker's forearm, was strange enough to have doctors scratching their heads.

This trail began when the man received a tattoo in Rochester, N.Y. in October 2011. A short while later, he noticed the raised, bumpy rash. He called his primary care physician.

Doctors initially treated the man's arm with topical steroids, thinking that the rash was allergic-contact dermatitis. But that only made the problem worse.

By the time dermatologist Dr. Mark Goldgeier saw the patient, it was clear that this was no simple allergy.

He performed a skin biopsy so he could take a closer look at the rash under a microscope. What he saw was startling: the sample was riddled with a wormlike bacterium related to tuberculosis.

"I explained [to the patient] that he had TB, and he had a look of horror on his face," Goldgeier said.

For the patient, the finding meant a trip to an infectious disease specialist to start up to a full year of treatment.

Goldgeier, meanwhile, called the Monroe County Health Department.

"As soon as biopsy came back," he said, "I knew something in the process of tattooing was involved -- the ink, the water used for dilution, the syringes, the dressings."

And so began a nationwide medical mystery.

An article published Wednesday in the New England Journal of Medicine describes how this one dermatologist helped connect the dots in an outbreak of tattoo-related atypical skin infections.

Dr. Byron Kennedy, public health specialist at Monroe County Department of Public Health, took over the case from Goldgeier. Kennedy first confirmed the results by repeating a skin biopsy on the patient. Once again, tendrils of mycobacterium chelonae, a type of tuberculosis-related skin bacteria, showed up in the sample.

Mycobacterium chelonae is a rapidly growing bug found in soil, dust, water, animals, hospitals, and contaminated pharmaceuticals. This family of bacteria does not commonly affect healthy individuals, but in patients with suppressed immune systems -- like those with HIV or on chemotherapy -- these bacteria can cause serious disease, often resulting in death.

The finding sent Kennedy and his associates to the tattoo parlor where the patient had been inked. Everything in the clinic was sterile, which made it unlikely that the infection had arisen there. But the tattoo artist, they learned, had been using a new gray premixed ink purchased in Arizona in April 2011; he used the ink between May and December 2011.

The ingredients of the ink -- pigment, witch hazel, glycerin, and distilled water -- seemed innocuous enough. But further examination revealed that the distilled water in the pigment was the likely culprit of the contamination.

The finding raised a number of questions -- not the least of which was how the bottles of premixed ink passed U.S. Food and Drug Administration regulations.

The U.S. Centers for Disease Control and Prevention acknowledged this gap in regulations Wednesday in its Morbidity and Mortality Weekly report.

"Under the Federal Food, Drug, and Cosmetic Act, tattoo inks are considered to be cosmetics, and the pigments used in the inks are color additives requiring premarket approval," the report says.

Armed gang fight breaks out in Venezuelan prison

Twenty-five people were killed and 43 others hurt in a prison battle in Venezuela as two armed gangs vied for control of a penitentiary near Caracas, authorities said on Monday.

Addiction Books For relaxation When 50 Shades of Grey doesn’t cut it.

The Science of Addiction: From Neurobiology to Treatment 

Carlton K. Erickson
312 pages 
Publisher: W. W. Norton and Company (2007)

Amazon Overview: Neuroscience is clarifying the causes of compulsive alcohol and drug use––while also shedding light on what addiction is, what it is not, and how it can best be treated––in exciting and innovative ways. Current neurobiological research complements and enhances the approaches to addiction traditionally taken in social work and psychology. However, this important research is generally not presented in a forthright, jargon-free way that clearly illustrates its relevance to addiction professionals. In The Science of Addiction, Carlton K. Erickson presents a comprehensive overview of the roles that brain function and genetics play in addiction.


The Addiction Solution: Unraveling the Mysteries of Addiction through Cutting-Edge Brain Science

David Kipper and Steven Whitney
304 pages
Publisher: Rodale Books (2010)

For decades addiction has been viewed and treated as a social and behavioral illness, afflicting people of “weak” character and “bad” moral fiber. However, recent breakthroughs in genetic technology have enabled doctors, for the first time, to correctly diagnose the disease and prove that addiction is an inherited, neuro-chemical disease originating in brain chemistry, determined by genetics, and triggered by stress. In their groundbreaking Addiction Breakthrough, David Kipper, MD, and Steven Whitney distill these exciting findings into a guide for the millions of adults who want to be free from the cycle of addiction, and for their loved ones who want to better understand it and to help.


In the Realm of Hungry Ghosts: Close Encounters with Addiction

Gabor Maté
520 pages 
Publisher: North Atlantic Books (2010) 

Based on Gabor Maté’s two decades of experience as a medical doctor and his groundbreaking work with the severely addicted on Vancouver’s skid row, In the Realm of Hungry Ghosts radically reenvisions this much misunderstood field by taking a holistic approach. Dr. Maté presents addiction not as a discrete phenomenon confined to an unfortunate or weak-willed few, but as a continuum that runs throughout (and perhaps underpins) our society; not a medical "condition" distinct from the lives it affects, rather the result of a complex interplay among personal history, emotional, and neurological development, brain chemistry, and the drugs (and behaviors) of addiction. Simplifying a wide array of brain and addiction research findings from around the globe, the book avoids glib self-help remedies, instead promoting a thorough and compassionate self-understanding as the first key to healing and wellness. 


Memoirs of an Addicted Brain: A Neuroscientist Examines his Former Life on Drugs 

Marc Lewis
336 pages 
Publisher: PublicAffairs (2012)

Marc Lewis’s relationship with drugs began in a New England boarding school where, as a bullied and homesick fifteen-year-old, he made brief escapes from reality by way of cough medicine, alcohol, and marijuana. In Berkeley, California, in its hippie heyday, he found methamphetamine and LSD and heroin. He sniffed nitrous oxide in Malaysia and frequented Calcutta’s opium dens. Ultimately, though, his journey took him where it takes most addicts: into a life of addiction, desperation, deception, and crime. But unlike most addicts, Lewis recovered and became a developmental psychologist and researcher in neuroscience. In Memoirs of an Addicted Brain, he applies his professional expertise to a study of his former self, using the story of his own journey through addiction to tell the universal story of addictions of every kind.


The Chemical Carousel: What Science Tells Us About Beating Addiction

Dirk Hanson
472 pages 
Publisher: BookSurge (2009)

A book for anyone concerned with the care and healing of addiction, substance abuse, and the latest advances in the area of addiction science. In The Chemical Carousel, science writer Hanson takes the reader on a voyage through the heady world of addiction science, from the lab to the clinic to the junky on the street. Hanson explains the workings of common neurotransmitters and documents the direct effect drugs and alcohol produce on the reward pathways of the brain. He shows how scientists and treatment professionals have finally given us an answer to the perennial question about addiction: Why can't those people just say no?


An Anatomy of Addiction: Sigmund Freud, William Halsted, and the Miracle Drug, Cocaine

Howard Markel
336 pages 
Publisher: Vintage (2012)

Acclaimed medical historian Howard Markel traces the careers of two brilliant young doctors--Sigmund Freud, neurologist, and William Halsted, surgeon--showing how their powerful addictions to cocaine shaped their enormous contributions to psychology and medicine. When Freud and Halsted began their experiments with cocaine in the 1880s, neither they, nor their colleagues, had any idea of the drug's potential to dominate and endanger their lives. An Anatomy of Addiction tells the tragic and heroic story of each man, accidentally struck down in his prime by an insidious malady: tragic because of the time, relationships, and health cocaine forced each to squander; heroic in the intense battle each man waged to overcome his affliction.


How to Change Your Drinking: a Harm Reduction Guide to Alcohol

Kenneth Anderson
86 pages 
Publisher: CreateSpace (2010)

This book is the first comprehensive compilation of harm reduction strategies aimed specifically at people who drink alcohol. Whether your goal is safer drinking, reduced drinking, or quitting alcohol altogether, this is the book for you. It contains a large and detailed selection of harm reduction tools and strategies which you can choose from to build your own individualized alcohol harm reduction program. There are many practical exercises to help people change their behaviors, including risk-ranking worksheets, drinking charts, goal choice worksheets, and many more. There are also innumerable practical tips from folks who "have been there" and have turned their drinking habits around for the better. 


Rethinking Substance Abuse: What the Science Shows, and What We Should Do about It

William R. Miller and Kathleen M. Carroll
320 pages 
Publisher: Guilford Press (2010) 

While knowledge on substance abuse and addictions is expanding rapidly, clinical practice still lags behind. This state-of-the-art book brings together leading experts to describe what treatment and prevention would look like if it were based on the best science available. The volume incorporates developmental, neurobiological, genetic, behavioral, and social–environmental perspectives. Tightly edited chapters summarize current thinking on the nature and causes of alcohol and other drug problems; discuss what works at the individual, family, and societal levels; and offer robust principles for developing more effective treatments and services.

Writers On The Edge: 22 Writers Speak About Addiction and Dependency

Diana Raab and James Brown
204 pages
Publisher: Modern History Press (2012)

Writers On The Edge offers a range of essays, memoirs and poetry written by major contemporary authors who bring fresh insight into the dark world of addiction, from drugs and alcohol, to sex, gambling and food. Editors Diana M. Raab and James Brown have assembled an array of talented and courageous writers who share their stories with heartbreaking honesty as they share their obsessions as well as the awe-inspiring power of hope and redemption. Frederick & Steven Barthelme, Kera Bolonik, Margaret Bullitt-Jonas, Maud Casey, Anna David, Denise Duhamel, B.H. Fairchild, Ruth Fowler, David Huddle Perie Longo, Gregory Orr, Victoria Patterson, Molly Peacock, Scott Russell Sanders, Stephen Jay Schwartz, Linda Gray Sexton, Sue William Silverman, Chase Twichell, and Rachel Yoder

WHEN YOUR HIGHER POWER FAILS YOU

It happens every time. Without fail. Without exception. I bet it's happened to you also. Just think about it. How often has your god failed you? Every single time. Every single time I have turned a human being into a god, or turned something man-made into an idol, or placed my trust, expectation, hope, and confidence in anything else but the one true God, my god has failed me. Some people are slow learners. I am one of them. I have made the same mistake countless times. And every single time, that's right, you've got it. It happens every time. Maybe I should be more careful when I place my trust, expectation, hope, and confidence in a human being. Maybe I should be more choosy with the human I choose. Not so. No matter the human, the same outcome will arise. My god will fail me. I did it again recently. I made the same mistake. But my mistake wasn't the human I chose. My mistake was the choice I made to pick a human. And guess what happened? You guessed it. My god failed me. But how can this happen, time and again? Easily. First, it happens when I fail to remember when I need not to forget. Never, ever, place what belongs to God in heaven in the hands of a human. My love and trust, my loyalty and faithfulness, my belief and confidence, my hope and expectation, must be placed in the Lord first and foremost, above all and everyone else - whether it be someone or something else, or whether it be myself. Second, it happens not because I forget, but because I don't realize and recognize what I have done. Hard habits sometimes die slowly, don't they? And slow habits die hard. It has been a hard lesson for me, and I have to be vigilant to ensure I don't unconsciously do what I have so often done. So what is the outcome of this all? My gods fail me. Every human I have ever made into a god, every person or thing I have ever turned into an idol, the result has always been the same. My false gods have failed me, hurt me, let me down, forsaken me, abandoned me, rejected me, broken me, fallen short, messed up, and a zillion other things. Seriously? Yes. Will the real God please stand up?

Researchers completing a new study on alcohol consumption have discovered that college-age students who binge drink are happier than those who don't.

 

Those who engaged in binge drinking tend to belong to so-called high-status groups: wealthy, white, male and active in fraternity life. And those who did not belong to the high-status groups could achieve similar levels of social acceptance through the act of binge drinking. In fact, the study results suggest that students engaged in the heavy drinking practice to elevate their social status amongst peers rather than to alleviate depression or anxiety.

"The present study offers another insight into the nature of a seemingly intractable social problem," the study released on Monday reads. "It is our hope that by drawing attention to the important social motivations underlying binge drinking, institutional administrators and public health professionals will be able to design and implement programs for students that take into account the full range of reasons that students binge drink."

The Washington Post reports that the study's co-author and Colgate University associate professor Carolyn Hsu presented some of the findings during the American Sociological Association gathering in Denver last week.

Interestingly, the study results compiled from surveying 1,600 college students also continues to support past evidence suggesting that binge drinking leads to a number of problems affecting the mind and body, including alcoholism, violence, poor grades and risky sexual behavior.

"I would guess it has to do with feeling like you belong and whether or not you're doing what a 'real' college student does," Hsu told LiveScience. "It seems to be more about certain groups getting to define what that looks like."

Binge drinking was defined as consuming more than four drinks in one occasion for women and more than five drinks for men. Sixty-four percent of respondents said they had engaged in the practice, compared with 36 percent who said they had not.

Those statistics differ from similar evidence gathered by the Centers for Disease Control and Prevention (CDC). The CDC's statistics measure binge drinking in the same quantity but limit the consumption period to two hours or fewer. Its results also found that the majority of binge drinkers (70 percent) were over the age of 26. The CDC has also found that 90 percent of alcohol consumed by people under the age of 21 is done in the form of binge drinking, compared with 75 percent among all U.S. adults.

The Five Keys to Mindful Communication

The first key of mindful communication, according to Chapman (2012), is having amindful presence. This means having an open mind, awake body and a tender heart. When you have a mindful presence, you give up expectations, stories about yourself and others, and acting on emotions.

You are fully in the present moment; your communication isn’t focused on the “me” and what the “me” needs, but the we.

Mindful listening is the second key to mindful communication. Mindful listening is about encouraging the other person. This means looking through the masks and pretense and seeing the value in the person and the strengths he or she possesses. It’s looking past the human frailties and flaws that we all have to see the authentic person and the truth in what that person is attempting to say.

Mindful speech, the third key, is about gentleness. Speaking gently means being effective in what you say. It’s about speaking in a way that you can be hard. To be gentle with our speech means being aware of when our own insecurities and fears are aroused to the point we are acting out of fear rather than acceptance.

Practicing self-compassion for our fear, envy, jealousy and self-doubts is more effective than focusing on others as being a threat or attempting to change them. When you use gentle speech, you are communicating acceptance to the other person and saying what is true, not an interpretation or an exaggeration or a minimization.

The key to mindful relationships is unconditional friendliness. Unconditional friendliness means accepting the ebb and flow of relationships. Sometimes you meet new friends, sometimes friends move on, sometimes there is joy and sometimes there is pain. Sometimes you’ll feel lonely, sometimes you’ll feel cherished and connected, and then you’ll feel lonely again.

Unconditional friendliness means that your acceptance of others is not dependent on them staying with you or agreeing with you. You don’t cling to relationships to avoid loss.

Mindful responsiveness is like playfulness.  Playfulness is the openness that you can have when you let go of preconceived ideas and strategies. It’s like creating something new. Imagine two skilled dancers who alternatively lead each other in creating a new dance in every interaction, never doing the same complete dance over and over. They respond in the moment to the message sent by the other. There are no rules or expectations and yet they both bring skillful behavior.

Mindful communication requires practice. If you choose to practice the keys, you might choose to focus on one at a time. Being willing to regulate your emotions is a prerequisite to mindful communication and mindfulness of your emotions is necessary for emotion regulation.

Mindfulness is a core skill for the emotionally sensitive.

 

References

Chapman, Susan Gillis. The Five Keys to Mindful Communication:  Using Deep Listening and Mindful Speech to Strengthen Relationships, Heal Conflicts and Acceomplish Your Goals. Boston: Shambhala, 2012.

ADDICTION charity Focus12 has received a huge financial boost after a codumentary about Russell Brand was shown last night.

The documentary Russell Brand: Addiction to Recovery resulted in an immediate boost in donations and inspired the managing director of Bury St Edmunds based Chevington Finance and Leasing to offer the charity £106,000 over three years.

Russell Brand attended Focus12, the Bury St Edmunds abstinence-based alcohol and drug rehabilitation centre, in 2003 and is now a patron of the charity, describing it as ‘a really excellent example of a small cost effective rehab that can help people change in dramatic ways’.

Chip Somers, Focus12’s chief executive, said: “Russell’s documentary and his work this year to raise the profile of abstinence based recovery has got people talking about addiction in a different way, and made them realise that there is a viable alternative to simply giving up on addicts, or parking them on methadone.

“We are blown away by the generosity of Chevington — this financial support will make a huge difference to us as a charity and will certainly mean we can continue to stay open and help those who need us for longer. Raising funds for a recovery charity has never been harder than it is at present, every day is literally a struggle to keep afloat and we are very grateful.”

Clive Morris, Managing Director of Chevington Finance and Leasing said: “My wife and I were incredibly touched by last night’s documentary, which inspired us to endorse the local treatment centre Focus12, and we have today agreed funding assistance for the charity of £106,000 over the next 4 years.

“We believe that as a successful, responsible and reliable company we have a duty to help local charities survive this recession and the work that Chip Somers and his team do is fantastic and we fully endorse their abstinence based programme and have seen what a difference it makes to people’s lives.”

London's secret music venue and their livestream act

With an invite-only door policy and super secret location, Boiler Room is London's most exclusive music venue. But elitism isn't the premise for its clandestine nature—in fact, anyone with an Internet connection can easily join in the fun. Using a simple webcam, the crew behind Boiler Room livestreams each set for the world to see free of charge, and each month more than a million viewers tune in to see performances by artists like James Blake, The xx, Roots Manuva, Neon Indian, Juan Maclean and more.

We recently chilled out to the smooth sounds of Brooklyn's How To Dress Well before rocking out to revered musician Matthew Dear, who brought down the house with an intense 40-minute DJ set. Keep an eye out for our interview with Dear, but for now you can get a little more insight into the underground music scene's most talked about livestream show by checking out our interview with assistant musical programmer and Boiler Room host Nic Tasker.

How important is it for Boiler Room to remain secret, at least in its location?

That is quite an important aspect of it, purely because it means when you do shows you don't get a lot of groupies, pretty much everyone in the room is either a friend of ours or one of the artist's. It helps to create a more relaxed atmosphere for the artist and I think they feel less pressure. They're also just able to chill out and be themselves more rather than having people being like, "Hi can I get your autograph?" If the artists are relaxed usually you get the best music.

It seems like there is more interaction among the crowd than at a typical venue, is that intentional?

It's definitely a social place. All the people that come down, most of them we know and they're all our friends. So they come down, hang, have a drink and just chill out, basically. From our very set-up, we do it with a webcam, we're not a highly professional organization but I think that's kind of the charm of it. The main thing is people come down with the right attitude.

How much of the show is prescribed?

I guess that depends on the artist. We never say anything. Literally, whatever they want to do—we're kind of the platform for them to do whatever they want, so if Matthew Dear wants to come and play an hour of noise with no beats, he can do that. That's fine with us, and I think that's why artists like coming to play for us. We're not like a club where you have to make people dance, we don't give a shit if people dance. It's nice if they do and it makes it more fun, but some nights you just get people appreciating the music, which is equally fun.

Is there a particular kind of artist you guys look for and ask to come perform?

No, not particularly, it's just whatever we're feeling. Thristian [Boiler Room's co-founder] has the main say on musical direction, but it's a massive team effort. In London there's five of us, New York there's two, LA there's one and Berlin there's two.

Tonight you had different set-ups for each artist, do you tailor their positioning in the room to their style?

It definitely depends on the act and what kind of music they do. With live bands we found what works nicely is having them opposite each other because it's like they're in rehearsal, like they're just jamming. Which is again trying to give them that chilled out feel that they're just at home jamming and there happens to be a camera there. For some of our shows we've had over 100,000 viewers. When you think of those numbers it's quite scary, but when you're in the room and it's all friends it creates that vibe that people don't mind. You can imagine if you had all those people in front of you it would be a very different situation.

Have you ever thought of Boiler Room as an East London version of Soul Train?

It's never crossed my mind like that, but I can see why you think that. I like to think of us as the new music broadcaster, kind of the new MTV, but obviously we operate in the underground scene mainly. But I like to think that what we do is as revolutionary as what they were doing. We're always growing into something new.

What's up next for Boiler Room?

We have had visual people in doing 3D mapping, and that's something we're looking forward to progressing—doing more with the visuals. We've got the upstairs as well, we're starting to do breakfast shows with some high profile DJs, we're going to be doing that regularly. Each will have an individual format. The next step is progressing the US shows, we're alternating weekly between New York and LA, so the next step is to take Boiler Room to America

Breaking Free of the Co-dependency Trap presents a groundbreaking developmental road map to guide readers away from their co-dependent behaviors and toward a life of wholeness and fulfillment.

Breaking Free of the Co-dependency Trap presents a groundbreaking developmental road map to guide readers away from their co-dependent behaviors and toward a life of wholeness and fulfillment.UK Citizens

This is the book that offers a different perspective on codependency and is strongly recommended by Dream Warrior Recovery as part of a solution based recovery. This bestselling book, now in a revised edition, radically challenges the prevailing medical definition of co-dependency as a permanent, progressive, and incurable addiction. Rather, the authors identify it as the result of developmental traumas that interfered with the infant-parent bonding relationship during the first year of life.US Citizens

Drawing on decades of clinical experience, Barry and Janae Weinhold correlate the developmental causes of co-dependency with relationship problems later in life, such as establishing and maintaining boundaries, clinging and dependent behaviors, people pleasing, and difficulty achieving success in the world. Then they focus on healing co-dependency, providing compelling case histories and practical activities to help readers heal early trauma and transform themselves and their primary relationships.